Therapeutic potential of iron chelators in diseases associated with iron mismanagement
Identifieur interne : 001C43 ( Main/Exploration ); précédent : 001C42; suivant : 001C44Therapeutic potential of iron chelators in diseases associated with iron mismanagement
Auteurs : Eugene D. Weinberg [États-Unis]Source :
- Journal of Pharmacy and Pharmacology [ 0022-3573 ] ; 2006-05.
English descriptors
- Teeft :
- Agents chemother, Aminoglycoside antibiotics, Antibiotic, Antineoplastic, Antineoplastic action, Antineoplastic activity, Atherosclerotic lesions, Autoimmune encephalomyelitis, Bacterial adhesion, Biochem, Biol, Boca raton, Bonsdorff, Cancer cells, Cell biol, Cell transplant patients, Chelating, Chelation, Chelator, Chelators, Chronic disease, Clin, Clinical trials, Considerable array, Defence, Deferiprone, Density lipoprotein, Desferrioxamine, Dexrazoxane, Excessive amounts, Fems immunol, Free iron, Free radic, Free radicals, Gallium nitrate, Haeme synthesis, Host cells, Host iron, Human lactoferrin, Human plasma, Hydroxyl radicals, Indiana university, Iron, Iron chelation, Iron chelation therapy, Iron chelator, Iron chelators, Iron deficiency, Iron depletion, Iron metabolism, Iron overload, Iron saturation, Iron withholding, Iron withholding defence system, Isonicotinoyl, Isonicotinoyl hydrazone, Lactoferrin, Lipid peroxidation, Lupus erythematosus, Molecular mass iron chelators, Oral candidiasis suppression, Other iron chelators, Pathogen, Pharmacol, Potential applications, Recent study, Rhlf, Risk factor, Staphylococcus epidermidis, Strand breaks, Therapeutic agents, Toxicity, Transferrin, Transferrin saturation, Varadhachary, Viral, Viral infections, Viral synthesis, Weinberg, Whole body iron loading.
Abstract
A considerable array of diseases are now recognized to be associated with misplacement of iron. Excessive deposits of the metal in sensitive tissue sites can result in formation of destructive hydroxyl radicals as well as in stimulation of growth of neoplastic and microbial cell invaders. To counteract potential iron damage, hosts employ the iron chelators, transferrin and lactoferrin. These proteins have been recently developed into pharmaceutical products. Additionally, a variety of low molecular mass iron chelators are being used/tested to treat whole body iron loading, and specific diseases for which the metal is a known or suspected risk factor.
Url:
DOI: 10.1211/jpp.58.5.0001
Affiliations:
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Excessive deposits of the metal in sensitive tissue sites can result in formation of destructive hydroxyl radicals as well as in stimulation of growth of neoplastic and microbial cell invaders. To counteract potential iron damage, hosts employ the iron chelators, transferrin and lactoferrin. These proteins have been recently developed into pharmaceutical products. Additionally, a variety of low molecular mass iron chelators are being used/tested to treat whole body iron loading, and specific diseases for which the metal is a known or suspected risk factor.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Indiana</li></region></list><tree><country name="États-Unis"><region name="Indiana"><name sortKey="Weinberg, Eugene D" sort="Weinberg, Eugene D" uniqKey="Weinberg E" first="Eugene D." last="Weinberg">Eugene D. 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